BDBM50119786 1,8-di(2-isoquinoliniumyl)octane; with diiodide ions::2,2'-(octane-1,8-diyl)diisoquinolinium iodide::CHEMBL104265::CHEMBL1669486

SMILES C(CCCC[n+]1ccc2ccccc2c1)CCC[n+]1ccc2ccccc2c1

InChI Key InChIKey=GMXBRECDYFCFAU-UHFFFAOYSA-N

Data  4 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50119786   

TargetAcetylcholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataIC50: 400nMAssay Description:Inhibition of human plasmatic BChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataKi:  620nMAssay Description:Dissociation constant for enzyme-inhibitor complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
University of Defence

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataKi:  980nMAssay Description:Dissociation constant for enzyme-inhibitor-substrate complex of human recombinant AChE by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataKi:  1.17E+4nMAssay Description:Binding affinity nicotinic acetylcholine receptor alpha-7 was evaluated by its ability to inhibit [3H]methyllycaconitine ([3H]-MLA) binding to rat br...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
University of Kentucky

Curated by ChEMBL
LigandPNGBDBM50119786(CHEMBL104265 | 1,8-di(2-isoquinoliniumyl)octane; w...)
Affinity DataKi:  6.55E+4nMAssay Description:Binding affinity for nicotinic acetylcholine receptor alpha4-beta2 was evaluated by its ability to inhibit [3H]NIC binding to rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/6/2012
Entry Details Article
PubMed