BDBM50120985 CHEMBL112200::[(S)-1-((6R,6aS)-6-Ethyl-4-methanesulfonyl-5-oxo-hexahydro-pyrrolo[3,2-b]pyrrole-1-carbonyl)-2-methyl-propyl]-carbamic acid tert-butyl ester

SMILES CCC1[C@@H]2[C@H](CCN2C(=O)[C@@H](NC(=O)OC(C)(C)C)C(C)C)N(C1=O)S(C)(=O)=O

InChI Key InChIKey=RVRXGFXYFFQPPA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50120985   

TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50120985([(S)-1-((6R,6aS)-6-Ethyl-4-methanesulfonyl-5-oxo-h...)
Affinity DataIC50: 6.20E+4nMAssay Description:Inhibitory concentration against hepatitis C virus NS3/4A protease on 4 hr pre-incubation in chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50120985([(S)-1-((6R,6aS)-6-Ethyl-4-methanesulfonyl-5-oxo-h...)
Affinity DataIC50: 1.40E+5nMAssay Description:Inhibitory concentration against hepatitis C virus NS3/4A protease on 18 h pre-incubation in fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50120985([(S)-1-((6R,6aS)-6-Ethyl-4-methanesulfonyl-5-oxo-h...)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibitory concentration against hepatitis C virus NS3/4A protease on 18 hr preincubation in chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepacivirus C)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50120985([(S)-1-((6R,6aS)-6-Ethyl-4-methanesulfonyl-5-oxo-h...)
Affinity DataIC50: 1.82E+5nMAssay Description:Inhibitory concentration against hepatitis C virus NS3/4A protease on 4 hr pre-incubation in fluorogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed