BDBM50121167 5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane-1,3'-indol]-5'-yl)benzonitrile::CHEMBL117461

SMILES Fc1cc(cc(c1)-c1ccc2NC(=O)C3(CCCC3)c2c1)C#N

InChI Key InChIKey=SIVWNWQUUDHRMU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50121167   

TargetProgesterone receptor(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50: 13nMAssay Description:Antagonist activity at progesterone receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProgesterone receptor(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50: 14nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Punjabi University

Curated by ChEMBL
LigandPNGBDBM50121167(5-fluoro-3-(2'-oxo-1',2'-dihydrospiro[cyclopentane...)
Affinity DataIC50: 230nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed