BDBM50121168 3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-2-one::CHEMBL119058

SMILES CC1(C)C(=O)Nc2ccc(cc12)-c1cccc(c1)[N+]([O-])=O

InChI Key InChIKey=RTMXGSLXWFFVFT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50121168   

TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50: 31nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50: 102nMAssay Description:Antagonist activity at progesterone receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetProgesterone receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50121168(3,3-Dimethyl-5-(3-nitro-phenyl)-1,3-dihydro-indol-...)
Affinity DataIC50: 509nMAssay Description:Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosolMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed