BDBM50121370 CHEMBL3622121

SMILES COc1cc(ccn1)N1CCC(CC1)Nc1ncc2OCCN(c3ccccc3OC(F)(F)F)c2n1

InChI Key InChIKey=COUFGTNLBNJCIM-UHFFFAOYSA-N

Data  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50121370   

TargetGamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2(Human)
Temple University

Curated by ChEMBL

LigandBDBM50121370(CHEMBL3622121)Copy SMILESCopy InChI

Affinity DataIC50: 21nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing human wild type APP75I cDNA assessed as reduction in amyloid beta peptides incubated for 1...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/4/2016
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL