BDBM50121602 4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino}-6-piperazin-1-yl-[1,3,5]triazin-2-ylamino)-ethyl]-phenol::CHEMBL150279

SMILES CN(CCCc1ccc(F)cc1)c1nc(NCCc2ccc(O)cc2)nc(n1)N1CCNCC1

InChI Key InChIKey=XYHKCYDTSYOWPV-UHFFFAOYSA-N

Data  2 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50121602   

TargetEstrogen receptor beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121602(4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino...)
Affinity DataIC50: 15nMAssay Description:In vitro inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor betaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121602(4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino...)
Affinity DataEC50:  200nMAssay Description:Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121602(4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino...)
Affinity DataIC50: 240nMAssay Description:In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor beta(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121602(4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity towards human Estrogen receptor 2 using [3H]17-beta-estradiol as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50121602(4-[2-(4-{[3-(4-Fluoro-phenyl)-propyl]-methyl-amino...)
Affinity DataKi:  380nMAssay Description:In vitro binding affinity towards human Estrogen receptor alpha using [3H]17-beta-estradiol as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed