BDBM50122396 1-(2,6-Dichloro-phenyl)-2-oxo-5-(3-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester::CHEMBL328752::methyl 1-(2,6-dichlorophenyl)-2-oxo-5-(3-(trifluoromethyl)phenyl)-1,2,3,4-tetrahydroquinazoline-7-carboxylate

SMILES COC(=O)c1cc2N(C(=O)NCc2c(c1)-c1cccc(c1)C(F)(F)F)c1c(Cl)cccc1Cl

InChI Key InChIKey=JPMVCHCFHWRPMX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50122396   

TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122396(methyl 1-(2,6-dichlorophenyl)-2-oxo-5-(3-(trifluor...)
Affinity DataIC50: 170nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122396(methyl 1-(2,6-dichlorophenyl)-2-oxo-5-(3-(trifluor...)
Affinity DataIC50: 170nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 14(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122396(methyl 1-(2,6-dichlorophenyl)-2-oxo-5-(3-(trifluor...)
Affinity DataIC50: 170nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article