BDBM50122676 CHEMBL274489::N-[2'-(4,5-Dimethyl-isoxazol-3-ylsulfamoyl)-4-oxazol-2-yl-biphenyl-2-yl]-3,3,N-trimethyl-butyramide

SMILES CN(C(=O)CC(C)(C)C)c1cc(ccc1-c1ccccc1S(=O)(=O)Nc1noc(C)c1C)-c1ncco1

InChI Key InChIKey=AXFKGEZDVMCYEO-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50122676   

TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122676(N-[2'-(4,5-Dimethyl-isoxazol-3-ylsulfamoyl)-4-oxaz...)
Affinity DataKi:  0.0100nMAssay Description:Inhibitory activity against human endothelin A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122676(N-[2'-(4,5-Dimethyl-isoxazol-3-ylsulfamoyl)-4-oxaz...)
Affinity DataKi:  10nMAssay Description:Antagonist activity at human ETA receptor expressed in CHO cells assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
TargetEndothelin receptor type B(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50122676(N-[2'-(4,5-Dimethyl-isoxazol-3-ylsulfamoyl)-4-oxaz...)
Affinity DataKi:  810nMAssay Description:Inhibitory activity against human endothelin B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed