BDBM50123658 3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl)-(3-hydroxy-phenyl)-methyl]-N-(3-fluoro-phenyl)-N-methyl-benzamide::CHEMBL155892

SMILES C[C@@H]1CN([C@@H](c2cccc(O)c2)c2cccc(c2)C(=O)N(C)c2cccc(F)c2)[C@@H](C)CN1CC=C

InChI Key InChIKey=LZXRQLIIMYJZDA-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50123658   

TargetDelta-type opioid receptor(Human)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataIC50: 3.40nMAssay Description:Antagonist activity at human delta opioid receptor in CD1 mouse assessed as electrically induced twitchesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataIC50: 1nMAssay Description:Agonist activity at mu-opioid receptor in guinea pig ileum assessed as inhibition of electrically induced twitchesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.180nMAssay Description:Displacement of [3H]DPDPE from mu opioid receptor in albino Sprague-Dawley rat after 90 mins by liquid scintillationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity of compound evaluated for Opioid receptor delta 1 isolated from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.180nMAssay Description:Binding affinity of compound evaluated for Opioid receptor delta 1 isolated from rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.460nMAssay Description:Displacement of [3H]DAMGO from kappa opioid receptor in albino Sprague-Dawley rat after 90 mins by liquid scintillationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Catania

Curated by ChEMBL
LigandPNGBDBM50123658(3-[(R)-((2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-y...)
Affinity DataKi:  0.460nMAssay Description:Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed