BDBM50123974 CHEMBL149534::N-Hydroxy-3-(4-p-tolylsulfamoyl-phenyl)-acrylamide::US8796330, 161

SMILES Cc1ccc(NS(=O)(=O)c2ccc(\C=C\C(=O)NO)cc2)cc1

InChI Key InChIKey=DQBCBVSLJCVWJK-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50123974   

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50123974(US8796330, 161 | CHEMBL149534 | N-Hydroxy-3-(4-p-t...)
Affinity DataIC50: 50nMT: 2°CAssay Description:For deacetylase assays, 20,000 cpm of the [3H]-metabolically labeled acetylated histone substrate (M. Yoshida et al., J. Biol. Chem. 265(28): 17174-1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/22/2014
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50123974(US8796330, 161 | CHEMBL149534 | N-Hydroxy-3-(4-p-t...)
Affinity DataIC50: 200nMAssay Description:Inhibitory activity on partially purified recombinant human Histone deacetylase 1 (HDAC-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
Aton Pharma

Curated by ChEMBL
LigandPNGBDBM50123974(US8796330, 161 | CHEMBL149534 | N-Hydroxy-3-(4-p-t...)
Affinity DataEC50:  1.00E+3nMAssay Description:Inhibition of acetylation of histone-4 in human T-24 cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Methylgene

US Patent
LigandPNGBDBM50123974(US8796330, 161 | CHEMBL149534 | N-Hydroxy-3-(4-p-t...)
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against human Histone deacetylase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed