BDBM50124122 CHEMBL3622800

SMILES [H][C@]12CC(O)=C(C(N)=O)C(=O)[C@@]1(O)C(O)=C1C(=O)c3c(O)cccc3[C@@](C)(O)[C@@]1([H])C2

InChI Key InChIKey=SRPCXEFYFVDUFQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50124122   

Target72 kDa type IV collagenase(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50124122(CHEMBL3622800)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of APMA-activated human recombinant MMP2 incubated for 5 mins using 4-nitrophenylacetate substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50124122(CHEMBL3622800)
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of recombinant human MMP-2 preincubated for 10 mins followed by Mca-PLGL-Dpa-AR-NH2 substrate addition and measured for 5 mins by fluoresc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50124122(CHEMBL3622800)
Affinity DataIC50: 2.52E+3nMAssay Description:Inhibition of APMA-activated human recombinant MMP9 incubated for 5 mins using 4-nitrophenylacetate substrate by esterase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2016
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Nanjing Agricultural University

Curated by ChEMBL
LigandPNGBDBM50124122(CHEMBL3622800)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibition of recombinant human MMP-8 using Mca-PLGL-Dpa-AR-NH2 as substrate preincubated for 10 mins followed by substrate addition and measured for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/19/2021
Entry Details Article
PubMed