BDBM50124415 CHEMBL3623462::US10413545, Compound 65::US9718813, Compound 65

SMILES CC1(C)N=C(N(C[C@@H]2CCN(C2)C(=O)C2CC2)C1=O)c1ccc(cc1)-c1c[nH]c2ccccc12

InChI Key InChIKey=LRPAHVDIDTWWBL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50124415   

TargetFatty acid synthase(Human)
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50124415(CHEMBL3623462 | US9718813, Compound 65 | US1041354...)
Affinity DataIC50: 41nMAssay Description:Inhibition of fatty acid synthase KR domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetFatty acid synthase(Human)
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50124415(CHEMBL3623462 | US9718813, Compound 65 | US1041354...)
Affinity DataIC50: 229nMpH: 7.5 T: 2°CAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
US Patent

TargetFatty acid synthase(Human)
University of South Alabama

Curated by ChEMBL
LigandPNGBDBM50124415(CHEMBL3623462 | US9718813, Compound 65 | US1041354...)
Affinity DataIC50: 229nMAssay Description:In this assay, inhibition of FASN activity is measured using 3H-acetyl-CoA and malonyl-CoA as substrates. 3H-Acetyl CoA is converted to 3H-palmitate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/2/2020
Entry Details
US Patent

Target1,5-anhydro-D-fructose reductase(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM50124415(CHEMBL3623462 | US9718813, Compound 65 | US1041354...)
Affinity DataIC50: 724nMpH: 7.5 T: 2°CAssay Description:10 μL assay buffer (100 mM KH2PO4 pH 7.5) was added to a 384-well clear plate (costar 3702). 0.3 μL compound (at concentrations of 30 μ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2018
Entry Details
US Patent