BDBM50124438 4-tert-Butyl-N-[2-cyclopropyl-6-(3-ethanesulfonylamino-propoxy)-5-(2-methoxy-phenoxy)-pyrimidin-4-yl]-benzenesulfonamide::CHEMBL368617

SMILES CCS(=O)(=O)NCCCOc1nc(nc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c1Oc1ccccc1OC)C1CC1

InChI Key InChIKey=GWVRRZASHHOARI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50124438   

TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124438(4-tert-Butyl-N-[2-cyclopropyl-6-(3-ethanesulfonyla...)
Affinity DataIC50: 33nMAssay Description:Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETB receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124438(4-tert-Butyl-N-[2-cyclopropyl-6-(3-ethanesulfonyla...)
Affinity DataIC50: 48nMAssay Description:Inhibitory concentration required against [125I]ET1 binding to membranes of CHO cells expressing human ETA receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed