BDBM50124521 CHEMBL174290::ethyl 4'-amino-5'-fluorospiro[hexahydropyridine-4,2'-(1',2'-dihydroquinazoline)]-1-carboxylate

SMILES CCOC(=O)N1CCC2(CC1)Nc1cccc(F)c1C(N)=N2

InChI Key InChIKey=FTNKTGJCALFVLR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124521   

TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124521(ethyl 4'-amino-5'-fluorospiro[hexahydropyridine-4,...)
Affinity DataIC50: 35nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124521(ethyl 4'-amino-5'-fluorospiro[hexahydropyridine-4,...)
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124521(ethyl 4'-amino-5'-fluorospiro[hexahydropyridine-4,...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed