BDBM50124668 2-(2,2-Dimethyl-cyclopropylmethyl)-4-(4-fluoro-phenyl)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one::CHEMBL154480

SMILES CC1(C)CC1Cn1ncc(-c2ccc(cc2)S(C)(=O)=O)c(-c2ccc(F)cc2)c1=O

InChI Key InChIKey=JHLKLBNQQLKWOW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124668   

TargetProstaglandin G/H synthase 1(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50124668(2-(2,2-Dimethyl-cyclopropylmethyl)-4-(4-fluoro-phe...)
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibitory activity against sensitive U-937 microsomal prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50124668(2-(2,2-Dimethyl-cyclopropylmethyl)-4-(4-fluoro-phe...)
Affinity DataIC50: 30nMAssay Description:In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Chinese hamster ovary (CHO) cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50124668(2-(2,2-Dimethyl-cyclopropylmethyl)-4-(4-fluoro-phe...)
Affinity DataIC50: 700nMAssay Description:In vitro inhibitory activity against prostaglandin G/H synthase 2 stably transfected in Human whole blood (HWB) cellMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed