BDBM50125054 CHEMBL3623003::US10130617, Example 2::WO-2014/191726, Example 2

SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1ccc(\C=C\C(O)=O)cc1

InChI Key InChIKey=HYPDMBONKGTBLC-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50125054   

TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 3.16E+3nMAssay Description:Agonist activity at progesterone receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 0.851nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 1nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2016
Entry Details Article
PubMed
TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 1.00E+3nMAssay Description:The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha LBD (GST)) was assessed in competition assays us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 850nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2019
Entry Details
Go to US Patent

TargetEstrogen receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)
Affinity DataIC50: 1nMAssay Description:Compounds were screened for their ability to displace a fluorescent labelled tracer ERβ ligand via time resolved fluorescent energy transfer usi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2023
Entry Details
Go to US Patent