BDBM50127135 CHEMBL3628551

SMILES Clc1cccc(Cn2nnc3c2C(=O)c2ccccc2C3=O)c1

InChI Key InChIKey=LOEIQXYQYANYTH-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50127135   

TargetTryptophan 2,3-dioxygenase(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50: 711nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetTryptophan 2,3-dioxygenase(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50: 712nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50: 767nMAssay Description:Inhibition of recombinant human IDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed
TargetIndoleamine 2,3-dioxygenase 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50: 769nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins by micropla...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Human)
National Health Research Institutes

Curated by ChEMBL
LigandPNGBDBM50127135(CHEMBL3628551)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human PTP1B preincubated with protein for 15 mins followed by DiFMUP addition for 1 hr measured by fluorescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2016
Entry Details Article
PubMed