BDBM50128266 CHEMBL3629001

SMILES Cn1ncc(c1-c1ccc(OCc2ccc3cc(F)ccc3n2)cc1)-c1ccncc1

InChI Key InChIKey=ACOOVXAIHUBKJQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50128266   

LigandPNGBDBM50128266(CHEMBL3629001)
Affinity DataIC50: 0.760nMAssay Description:Inhibition of recombinant human PDE10A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128266(CHEMBL3629001)
Affinity DataIC50: 760nMAssay Description:Inhibition of recombinant human PDE4B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128266(CHEMBL3629001)
Affinity DataIC50: 9.73E+3nMAssay Description:Inhibition of recombinant human PDE4A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128266(CHEMBL3629001)
Affinity DataIC50: 1.11E+5nMAssay Description:Inhibition of recombinant human PDE3A assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3B(Human)
Washington University

Curated by ChEMBL
LigandPNGBDBM50128266(CHEMBL3629001)
Affinity DataIC50: 1.51E+5nMAssay Description:Inhibition of recombinant human PDE3B assessed as reduction of [3H]-cAMP hydrolysis preincubated for 5 mins followed by [3H]-cAMP addition measured a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2016
Entry Details Article
PubMed