BDBM50128648 1-Benzyl-4-[4-(4-chloro-phenoxy)-benzenesulfonyl]-piperidine-4-carboxylic acid hydroxyamide::1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-hydroxypiperidine-4-carboxamide::CHEMBL79433

SMILES ONC(=O)C1(CCN(Cc2ccccc2)CC1)S(=O)(=O)c1ccc(Oc2ccc(Cl)cc2)cc1

InChI Key InChIKey=IMKDKHQDFFLOKK-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50128648   

LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ADAMTS-4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetStromelysin-1(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 55nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-9.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 301nMAssay Description:In vitro inhibitory activity against tumor necrosis factor alpha converting enzyme (TACE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Matrix metalloprotease-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 1nMAssay Description:Inhibition of Matrix metalloprotease-8More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 7nMAssay Description:Inhibition of Matrix metalloprotease-14More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetCollagenase 3(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-13.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 801nMAssay Description:In vitro inhibitory activity against matrix metalloprotease-1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetMatrilysin(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 925nMAssay Description:Inhibition of Matrix metalloprotease-7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
LigandPNGBDBM50128648(1-benzyl-4-(4-(4-chlorophenoxy)phenylsulfonyl)-N-h...)
Affinity DataIC50: 420nMAssay Description:Inhibition of ADAMTS-5 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed