BDBM50129131 CHEBI:83275::Hypothemycin::US10434085, Compound hypothemycin

SMILES COc1cc(O)c2c(c1)[C@H]1O[C@@H]1C[C@H](O)[C@H](O)C(=O)/C=C\C[C@H](C)OC2=O

InChI Key InChIKey=SSNQAUBBJYCSMY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50129131   

LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TAK1 (1 to 303 residues)/TAB1 (437 to end residues) expressed in baculovirus infected Sf9 insec...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Human)
University of North Carolina At Greensboro

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 33nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2016
Entry Details Article
PubMed
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 33nMAssay Description:The assay was performed at BSP Biosience Inc. (5Z)-7-oxozeaenol was used as a positive control. Analogue 3 was not tested due to the short-term stabi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details
US Patent

TargetSerine/threonine-protein kinase D1(Human)
University of Pittsburgh

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 500nMAssay Description:Inhibition of PKD1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/13/2024
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Ohio University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 663nMAssay Description:Inhibition of human GSK-3beta preincubated for 3 hrs followed by ATP and substrate addition measured by serial dilution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Ohio University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50129131BDBM50129131(CHEBI:83275 | Hypothemycin | US10434085, Compound ...)
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of human GSK-3beta incubated with substrate in presence of ATP measured by serial dilution assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed