BDBM50130151 (S)-1-[(4S,6S)-4-(5-Fluoro-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol::CHEMBL78202

SMILES C[C@H]1C[C@H](CCN1C[C@H](O)COc1cccc2[nH]ccc12)c1cc2cc(F)ccc2s1

InChI Key InChIKey=VXBBUYIZAQUAJB-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50130151   

TargetSodium-dependent serotonin transporter(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130151((S)-1-[(4S,6S)-4-(5-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  4.20nMAssay Description:In vitro affinity at the 5-HT reuptake site using [3H]paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130151((S)-1-[(4S,6S)-4-(5-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  16nMAssay Description:Inhibition of 5-HT induced [35S]GTP-gamma-S, binding at human cloned 5-HT 1A receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130151((S)-1-[(4S,6S)-4-(5-Fluoro-benzo[b]thiophen-2-yl)-...)
Affinity DataKi:  37nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 1A receptor by [3H]8-OH-DPAT displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed