BDBM50130168 (S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-methyl-benzo[b]thiophen-2-yl)-piperidin-1-yl]-propan-2-ol::(S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-2-methyl-4-(4-methylbenzo[b]thiophen-2-yl)piperidin-1-yl)propan-2-ol::CHEMBL311964

SMILES C[C@H]1C[C@@H](CCN1C[C@H](O)COc1cccc2[nH]ccc12)c1cc2c(C)cccc2s1

InChI Key InChIKey=RBTQWIMQKBKIOV-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50130168   

TargetSodium-dependent serotonin transporter(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130168((S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-...)
Affinity DataKi:  0.440nMAssay Description:In vitro affinity at the 5-HT reuptake site using [3H]paroxetine as radioligand in rat frontal cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130168((S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-...)
Affinity DataKi:  0.440nMAssay Description:Displacement of [3H]paroxetine from 5HT reuptake siteMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130168((S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-...)
Affinity DataKi:  6.85nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130168((S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-...)
Affinity DataKi:  6.90nMAssay Description:In vitro binding affinity at 5-hydroxytryptamine 1A receptor by [3H]8-OH-DPAT displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50130168((S)-1-(1H-Indol-4-yloxy)-3-[(4S,6R)-2-methyl-4-(4-...)
Affinity DataKi:  8.80nMAssay Description:Inhibition of 5-HT induced [35S]GTP-gamma-S, binding at human cloned 5-HT 1A receptors.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed