BDBM50130841 CHEMBL3634745

SMILES Fc1ccc(cc1)-c1[nH]c(=O)ccc1-c1ccc(OCc2ccc3ccccc3n2)cc1

InChI Key InChIKey=OOOKPENMJKOYJM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50130841   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Rat)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 4.30nMAssay Description:Inhibition of rat PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity assa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Mouse)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of mouse PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 mins by scintillation proximity as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 6.70nMAssay Description:Binding affinity to human 5HT2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to LTD4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to dopamine receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 220nMAssay Description:Antagonist activity at human 5HT2bMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 1.20E+3nMAssay Description:Binding affinity to norepinephrine transporter (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Human)
Glenmark Research Centre

Curated by ChEMBL
LigandPNGBDBM50130841(CHEMBL3634745)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human PDE10A using [3H]cAMP/cAMP as substrate assessed as hydrolysis of [3H]cAMP to [3H]AMP after 30 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2016
Entry Details Article
PubMed