BDBM50132677 CHEMBL109517::Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]hept-2-ylmethyl)-amine

SMILES CN(C)C[C@@H]1C2CCC(C2)[C@H]1c1ccc2ccccc2c1

InChI Key InChIKey=NWCPOGFPLUASJD-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50132677   

TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 20nMAssay Description:In vitro ability of compound to inhibit 5-HT re-uptake of radiolabeled [3H]-tritium transmitter into synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 93nMAssay Description:In vitro inhibition of DA re-uptake into synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 34nMAssay Description:In vitro inhibition of [3H]NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 34nMAssay Description:Inhibition of NET (unknown origin) assessed as reduction of [3H]-NE re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SERT (unknown origin) assessed as reduction of [3H]5-HT re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataIC50: 93nMAssay Description:Inhibition of DAT (unknown origin) assessed as reduction of [3H]-DA re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132677(Dimethyl-((2R,3R)-3-naphthalen-2-yl-bicyclo[2.2.1]...)
Affinity DataKi:  149nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed