BDBM50132682 CHEMBL113136::[(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-ylmethyl]-dimethyl-amine

SMILES CN(C)C[C@H]1C2CCC(CC2)[C@@H]1c1cccc(Cl)c1

InChI Key

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50132682   

TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 44nMAssay Description:In vitro inhibition of [3H]NE re-uptake into synaptosomeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 44nMAssay Description:Inhibition of NET (unknown origin) assessed as reduction of [3H]-NE re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-Nisoxetine from norepinephrine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 165nMAssay Description:Displacement of [3H]WIN-35428 from Dopamine transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 165nMAssay Description:Inhibition of DAT (unknown origin) assessed as reduction of [3H]-DA re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 303nMAssay Description:Inhibition of SERT (unknown origin) assessed as reduction of [3H]5-HT re-uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132682([(2S,3S)-3-(3-Chloro-phenyl)-bicyclo[2.2.2]oct-2-y...)
Affinity DataIC50: 303nMAssay Description:Displacement of [3H]-citalopram from Serotonin transporterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed