BDBM50132981 4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quinoline::CHEMBL129153

SMILES Cc1[nH]nc(c1-c1ccnc2ccccc12)-c1cccc(C)n1

InChI Key InChIKey=AMZUNRUJZDTWPE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132981   

TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50: 24nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50: 82nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50: 148nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)
Affinity DataIC50: 250nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed