BDBM50132986 4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)quinoline::4-[3-(3-Trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-quinoline::CHEMBL129678

SMILES FC(F)(F)c1cccc(c1)-c1n[nH]cc1-c1ccnc2ccccc12

InChI Key InChIKey=UZNTWHBHIHKRLK-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50132986   

TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50: 217nMAssay Description:Inhibition of TGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50: 217nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50: 355nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)
Affinity DataIC50: 524nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed