BDBM50133140 9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(Z)-ylidene]-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL134277

SMILES CC1=CC(C)(C)Nc2ccc3-c4cc(F)ccc4O\C(=C/c4ccsc4)c3c12

InChI Key InChIKey=MYDJWFCWWHPKCH-UHFFFAOYSA-N

Data  3 KI  3 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50133140   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataEC50:  0.710nMAssay Description:Agonistic activity against human progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataEC50:  5.5nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataKi:  84nMAssay Description:Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataIC50: 215nMAssay Description:Inhibition of human androgen receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataKi:  669nMAssay Description:Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133140(9-Fluoro-2,2,4-trimethyl-5-[1-thiophen-3-yl-meth-(...)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory activity against human Mineralocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed