BDBM50133144 9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]-2,2,4-trimethyl-2,5-dihydro-1H-6-oxa-1-aza-chrysene::CHEMBL335996

SMILES COc1ccccc1\C=C1/Oc2ccc(F)cc2-c2ccc3NC(C)(C)C=C(C)c3c12

InChI Key InChIKey=IAUDUYJHOKBQLW-UHFFFAOYSA-N

Data  3 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50133144   

TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataEC50:  0.930nMAssay Description:Agonistic activity against human progesterone receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataKi:  3.80nMAssay Description:Binding affinity towards human progesterone receptor A isoform using progesterone as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataEC50:  8nMAssay Description:Agonistic activity against human progesterone receptor in T47D breast cancer cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataIC50: 90nMAssay Description:Inhibition of human glucocorticoid receptor at 10e-12 to 10e-5 MMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataKi:  277nMAssay Description:Inhibition of Dexamethasone binding to human glucocorticoid receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50133144(9-Fluoro-5-[1-(2-methoxy-phenyl)-meth-(Z)-ylidene]...)
Affinity DataKi:  439nMAssay Description:Inhibition of DHT binding to human androgen receptor expressed in baculovirus SF-12 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed