BDBM50134469 CHEMBL3746344

SMILES Fc1ccc(cc1)N1CCCn2nc(COc3ccccc3)cc2C1=O

InChI Key InChIKey=CAWROKQLIKIEEA-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50134469   

TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134469(CHEMBL3746344)
Affinity DataEC50:  87nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134469(CHEMBL3746344)
Affinity DataEC50:  87.1nMAssay Description:Positive allosteric modulation of human mGlu5 expressed in HEK293 cells assessed as glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 3(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50134469(CHEMBL3746344)
Affinity DataEC50:  540nMAssay Description:Antagonist activity at human mGlu3 expressed in HEK293 cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2017
Entry Details Article
PubMed