BDBM50135451 (2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroethyl-phenyl)-3-methyl-octa-2,4,6-trienoic acid::CHEMBL133896

SMILES CCOc1c(cc(cc1\C(C)=C/C=C/C(/C)=C/C(O)=O)C(F)(F)C(F)(F)F)C(C)C

InChI Key InChIKey=IXJIVOFEKLAPRC-UHFFFAOYSA-N

Data  6 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50135451   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  99nMAssay Description:In vitro agonist efficacy against PPAR gamma along with 100 nM BRL-49653More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  0.700nMAssay Description:In vitro agonistic activity against PPAR gamma along with 100 nM BRL-49653More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataEC50:  92nMAssay Description:In vitro agonistic activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataIC50: 5.30nMAssay Description:In vitro antagonist activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  6.30nMAssay Description:In vitro agonistic activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  7.70nMAssay Description:Binding affinity against RXR gamma receptor using [3H]9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]9-cis-RA from RXR beta receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against RAR beta receptor using [3H]ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity against RAR alpha receptor using [3H]ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135451((2E,4E,6Z)-7-(2-Ethoxy-3-isopropyl-5-pentafluoroet...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ATRA from RAR gamma receptor in CV-1 cells; Not testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed