BDBM50135460 (2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-isopropyl-biphenyl-3-yl]-3-methyl-octa-2,4,6-trienoic acid::CHEMBL133915

SMILES CC(C)c1cc(cc(\C(C)=C/C=C/C(/C)=C/C(O)=O)c1OCC(F)F)-c1ccc(F)cc1

InChI Key InChIKey=JMSNTCCDXKQCFG-UHFFFAOYSA-N

Data  6 KI  1 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50135460   

TargetPeroxisome proliferator-activated receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataEC50:  1.30nMAssay Description:In vitro agonistic activity against PPAR gamma along with 100 nM BRL-49653More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataEC50:  32nMAssay Description:In vitro agonist efficacy against PPAR gamma along with 100 nM BRL-49653More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataIC50: 2.20nMAssay Description:In vitro antagonist activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi:  0.800nMAssay Description:In vitro agonistic activity against RXR alpha in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]9-cis-RA from RXR beta receptor in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor RXR-gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity against RXR gamma receptor using [3H]9-cis-RA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor beta(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi:  2.11E+3nMAssay Description:Binding affinity against RAR beta receptor using [3H]ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor alpha(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi:  4.56E+3nMAssay Description:Binding affinity against RAR alpha receptor using [3H]ATRA as radioligand in CV-1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRetinoic acid receptor gamma(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50135460((2E,4E,6Z)-7-[4-(2,2-Difluoro-ethoxy)-4'-fluoro-5-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]ATRA from RAR gamma receptor in CV-1 cells; Not testedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed