BDBM50136604 CHEMBL138036::[3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-yl)-phenyl]-methanol

SMILES C[C@H]1CN(CCc2ccccc2)CC[C@@]1(C)c1cccc(CO)c1

InChI Key InChIKey=KUPRSXQYRVHMQY-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50136604   

TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136604([3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-y...)
Affinity DataIC50: 2.10nMAssay Description:Concentration required to inhibit agonist (loperamide) stimulated [35S]GTP-gamma-S, binding to membranes containing the cloned human mu opioid recept...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136604([3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-y...)
Affinity DataKi:  11nMAssay Description:Inhibition of binding of the non-selective opioid antagonist, [3H]diprenorphine, to cloned human mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136604([3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-y...)
Affinity DataKi:  270nMAssay Description:Inhibition of [3H]diprenorphine binding to the cloned human delta opioid receptors using 10 uM concentration of the compoundMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Adolor

Curated by ChEMBL
LigandPNGBDBM50136604([3-((3R,4R)-3,4-Dimethyl-1-phenethyl-piperidin-4-y...)
Affinity DataKi:  840nMAssay Description:Binding affinity at cloned human kappa opioid receptor by [3H]diprenorphine displacement.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed