BDBM50138010 3-Amino-N-methylmorphinan::CHEMBL48420::US10766864, Example 114

SMILES CN1CC[C@]23CCCC[C@H]2[C@H]1Cc1ccc(N)cc31

InChI Key InChIKey=CYPHSPITDGFDMD-UHFFFAOYSA-N

Data  6 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50138010   

TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  7.90nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  7.90nMAssay Description:Binding affinity against opioid receptor mu 1 using [3H]DAMGO as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  110nMAssay Description:Displacement of [3H]-U69,593 from human kappa opioid receptor expressed in CHO cells after 60 mins by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  110nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]-U-69,593 as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataIC50: 550nMAssay Description:Affinities of various compounds were measured in vitro using competitive radioligand binding assays. Serial dilutions of test compounds were incubate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  1.50E+3nMAssay Description:Displacement of [3H]-naltrindole from human delta opioid receptor expressed in CHO cells after 3 hrs by scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50138010(3-Amino-N-methylmorphinan | CHEMBL48420 | US107668...)
Affinity DataKi:  1.50E+3nMAssay Description:Binding affinity against opioid receptor delta 1 using [3H]naltrindole as radioligand in guinea pig brain membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed