BDBM50139151 CHEMBL3764870

SMILES OC1(CNC1)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCc2ccc(Oc3ccnc4NC(=O)CCc34)cc2C1

InChI Key InChIKey=ALVMSWWSJKOZJK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50139151   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50139151(CHEMBL3764870)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human ERG using tracer red fluorescent probeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50139151(CHEMBL3764870)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of B-Raf V600E mutant (unknown origin) preincubated for 20 mins followed by addition of 2 microM Biotin-DRGFPRARYRARTTNYNSSRSRFYSGFNSRPRGR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50139151(CHEMBL3764870)
Affinity DataIC50: 854nMAssay Description:Inhibition of B-Raf V600E mutant in human A375 cell line assessed as inhibition of ERK phosphorylation for 3 hrs with compound by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2017
Entry Details Article
PubMed