BDBM50139763 CHEMBL306657::[(E)-(9S,10S,14S,18S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,17,20-trioxo-10-(4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid::[(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmethyl-8,20-dioxo-17-(S)-oxo-10-((1S,4S)-4-phosphonomethyl-phenyl)-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid

SMILES NC(=O)C[C@@H]1NC(=O)C2(CCCCC2)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C[C@@H](Cc2cccc3ccccc23)CNC1=O)c1ccc(CP(O)(O)=O)cc1

InChI Key InChIKey=YWOITRAWXNSFNB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50139763   

TargetGrowth factor receptor-bound protein 2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 2nMAssay Description:In vitro binding affinity in extracellular ELISA-based assay for Grb2 SH2 domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 1.40nMAssay Description:In vitro Growth factor receptor bound protein 2-binding affinity in in surface plasmon resonance (SPR) methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGrowth factor receptor-bound protein 2(Human)
National Cancer Institute-Frederick

Curated by ChEMBL
LigandPNGBDBM50139763([(E)-(S)-18-Carbamoylmethyl-14-naphthalen-1-ylmeth...)
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused Grb2-SH2 domain (unknown origin) by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed