BDBM50140097 1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phenyl)-6-methyl-3-{(R)-2-[(thiazol-2-ylmethyl)-amino]-propyl}-1H-pyrimidine-2,4-dione::CHEMBL280664

SMILES COc1cccc(c1F)-c1c(C)n(Cc2c(F)cccc2F)c(=O)n(C[C@@H](C)NCc2nccs2)c1=O

InChI Key InChIKey=SHSXQSNMXRKMPX-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50140097   

TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140097(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataIC50: 6.10nMAssay Description:In vitro inhibition of [Ca2+] influx in RBL cells expressing Gonadotropin-releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140097(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  6nMAssay Description:Inhibition of GnRH receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140097(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  13nMAssay Description:Binding affinity evaluated by the ability to inhibit des-Gly10[125I]Tyr5,D-Leu6,NMeLeu7,Pro9-NEt]- Gonadotropin-releasing hormone binding to cloned h...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140097(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  820nMAssay Description:In vivo inhibition of monkey Gonadotropin releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetGonadotropin-releasing hormone receptor(Rat)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50140097(1-(2,6-Difluoro-benzyl)-5-(2-fluoro-3-methoxy-phen...)
Affinity DataKi:  1.00E+4nMAssay Description:In vivo inhibition of rat Gonadotropin releasing hormone receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed