BDBM50140176 CHEMBL3394285

SMILES ONC(=O)\C=C\c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=ABKAFUZUCJSIKV-UHFFFAOYSA-N

Data  22 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 22 hits for monomerid = 50140176   

TargetInterstitial collagenase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP1 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 2.15E+4nMAssay Description:Inhibition of human recombinant TACE expressed in Sf21 cells using MCA-PLAQAV-Dpa-RSSSR-NH2 as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-14(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP14 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP13 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP12 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetStromelysin-2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP10 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP9 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP8 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP7 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetStromelysin-1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP3 expressed in Escherichia coli using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human recombinant MMP1 expressed in yeast using (5-FAM/QXLTM) FRET peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 4.11E+3nMAssay Description:Inhibition of full length C-terminal GST-tagged human HDAC1 expressed in Sf9 cells using (Arg-His-Lys-Lys(Ac)) as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 11(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 5.53E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC11 expressed in baculovirus expression system using (Arg-His-Lys-Lys(Ac)) as substrate by plate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetPolyamine deacetylase HDAC10(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 6.32E+3nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC10 expressed in Sf9 cells using (Arg-His-Lys-Lys(Ac)) as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 9(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of C-terminal His-tagged human HDAC9 expressed in baculovirus expression system using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 8(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 954nMAssay Description:Inhibition of full length human HDAC8 expressed in Escherichia coli using (Arg-His-Lys(Ac)-Lys(Ac)) as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 7(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC7 expressed in baculovirus expression system using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 183nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC6 expressed in Sf9 cells using (Arg-His-Lys-Lys(Ac)) as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 5(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 3.47E+4nMAssay Description:Inhibition of full length N-terminal GST-tagged human HDAC5 expressed in Sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by plate reader ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 4(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of N-terminal GST-tagged human HDAC4 expressed in baculovirus expression system using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by plate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 3(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 5.37E+3nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC3 expressed in baculovirus expression system using (Arg-His-Lys-Lys(Ac)) as substrate by pl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50140176(CHEMBL3394285)
Affinity DataIC50: 6.36E+3nMAssay Description:Inhibition of full length C-terminal His-tagged human HDAC2 expressed in Sf9 cells using (Arg-His-Lys-Lys(Ac)) as substrate by plate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/4/2017
Entry Details Article
PubMed