BDBM50140946 8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-ethoxy]-2H-pyrazol-3-yl}-1,3-dipropyl-3,7-dihydro-purine-2,6-dione::CHEMBL33455

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1cc(OCC(=O)N2CCN(CC2)c2ccccc2)nn1C

InChI Key InChIKey=BVHLYIIHYJFKSI-UHFFFAOYSA-N

Data  10 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50140946   

TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataIC50: 70nMAssay Description:Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataIC50: 65nMAssay Description:Inhibitory activity against cAMP production in CHO cells transfected with human A2B adenosine receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity of compound for displacement of specific [3H]- DPCPX binding at human A2B receptors expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  12nMAssay Description:Binding affinity of compound for displacement of [3H]DPCPX binding in HEK293 membranes expressing human A2B adenosine receptorsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  250nMAssay Description:Displacement of specific [3H]DPCPX binding at human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi:  260nMAssay Description:Displacement of specific [3H]DPCPX binding at human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity of compound for displacement of specific [3H]MRE3008-F20 binding at human A3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity of compound for displacement of specific [3H]ZM-241385 binding at human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity of compound for displacement of specific [3H]MRE3008-F20 binding at human A3 receptors expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50140946(8-{2-Methyl-5-[2-oxo-2-(4-phenyl-piperazin-1-yl)-e...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity of compound for displacement of specific [3H]ZM-241385 binding at human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed