BDBM50142023 3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-one::CHEMBL175321

SMILES Oc1ccc2\C(CCc2c1)=C1/C(=O)Nc2ccccc12

InChI Key InChIKey=VZCJCGYMMSXPBM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142023   

TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142023(3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of Cyclin-dependent kinase 2 cyclin AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142023(3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of receptor Tyrosine kinase A, TrkA (nerve growth factor receptor)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142023(3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of c-Raf1 kinaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2012
Entry Details Article
PubMed
TargetHigh affinity nerve growth factor receptor(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50142023(3-(5-Hydroxy-indan-1-ylidene)-1,3-dihydro-indol-2-...)
Affinity DataIC50: 6nMAssay Description:Inhibition of GST-fused TrkA (unknown origin) expressed in SF9 cells using H2N-RRRAAAEEIYGEINH2 peptide as substrate preincubated with ATP and Mg and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/29/2022
Entry Details Article
PubMed