BDBM50142688 CHEMBL3759494

SMILES CCOC(=O)c1c(CSc2c(C)cc(C)cc2C)[nH]c2c1cc(O)c1ccccc21

InChI Key InChIKey=JWESPVQKQQXJKC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50142688   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant 5-LOX expressed in Escherichia coli BL21 using arachidonic acid as substrate assessed as LTB4 formation preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50: 370nMAssay Description:Inhibition of 5-LOX in human intact polymorphonuclear leukocytes preincubated for 15 mins with CaCl2, A23187 measured after 10 mins by HPLC analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Second University of Naples

Curated by ChEMBL
LigandPNGBDBM50142688(CHEMBL3759494)
Affinity DataIC50: 1.93E+3nMAssay Description:Inhibition of IL-1beta-activated m-PGES-1 in microsome of human A549 cells assessed as PGE2 formation preincubated for 15 mins followed by PGH2 addit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/8/2017
Entry Details Article
PubMed