BDBM50142736 (E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dioxo-hex-5-enoic acid::CHEMBL48573

SMILES OC(=O)C(=O)CC(=O)C=Cc1cccn1Cc1ccc(F)cc1

InChI Key InChIKey=CQKYZZBUZNFHBT-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50142736   

TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142736((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibitory activity against HIV-1 integrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50142736((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 6.10E+4nMAssay Description:Inhibitory activity against HIV-1 integrase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetIntegrase(Human immunodeficiency virus type 1)
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50142736((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 26nMAssay Description:Inhibition of strand transfer activity of recombinant HIV1 integrase using 5'-end-labeled 21-mer double-stranded DNA as substrate after 60 mins by el...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
"Sapienza" Universit£

Curated by ChEMBL
LigandPNGBDBM50142736((E)-6-[1-(4-Fluoro-benzyl)-1H-pyrrol-2-yl]-2,4-dio...)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of RNase H activity of recombinant HIV1 reverse transcriptase using poly(dC)-[3H]poly(rG) as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed