BDBM50143606 20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapentacyclo[10.5.3.01,13.02,10.04,8]icosa-2(10),3,5,8-tetraen-6-amine::CHEMBL56171

SMILES Nc1nc2cc3c(C[C@@H]4C5CCCC[C@]35CCN4CC3CCC3)cc2s1

InChI Key

Data  3 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50143606   

TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143606(20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapent...)
Affinity DataKi:  0.790nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143606(20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapent...)
Affinity DataKi:  7.10nMAssay Description:Inhibition of [3H]-DAMGO binding to Opioid receptor mu 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143606(20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapent...)
Affinity DataEC50:  29nMAssay Description:Agonistic activity against kappa opioid receptor in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143606(20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapent...)
Affinity DataKi:  230nMAssay Description:Inhibition of [3H]naltrindole binding to opioid receptor delta 1 of Chinese hamster ovary membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50143606(20-cyclobutylmethyl-(1R,12R)-7-thia-5,20-diazapent...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonistic activity against Opioid receptor mu 1 in Chinese hamster ovary membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed