BDBM50143746 (4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenylamino-4'-methyl-[1,4']bipiperidinyl-1'-yl)-methanone::CHEMBL61374

SMILES Cc1nc(nc(C)c1C(=O)N1CCC(C)(CC1)N1CCC(CC1)N(c1ccccc1)c1ccccc1)-c1ccccc1

InChI Key InChIKey=NZFYIDWRHCRROY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50143746   

TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143746((4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenyl...)
Affinity DataIC50: 16.5nMAssay Description:Migration of compound was evaluated in cell migration assay with C-C chemokine receptor type 5-transfected L1.2 cells oractivated human peripheral bl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143746((4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenyl...)
Affinity DataIC50: 23nMAssay Description:Antagonistic activity against monkey C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143746((4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenyl...)
Affinity DataIC50: 31nMAssay Description:Rises in intracellular [Ca2+] levels by using [Ca2+] sensitive Fluo4 dye in C-C chemokine receptor type 5-transfected CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 5(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50143746((4,6-Dimethyl-2-phenyl-pyrimidin-5-yl)-(4-diphenyl...)
Affinity DataIC50: 8.5nMAssay Description:Antagonistic activity against human C-C chemokine receptor type 5.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed