BDBM50144193 CHEMBL65484::Dicyclopropylmethyl-propyl-[4-(2,4,6-trimethoxy-phenyl)-pyrimidin-2-yl]-amine

SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(OC)cc(OC)cc1OC

InChI Key InChIKey=VVOKUTLMKHSKLC-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50144193   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144193(Dicyclopropylmethyl-propyl-[4-(2,4,6-trimethoxy-ph...)
Affinity DataKi:  15nMAssay Description:Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]CRF from CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144193(Dicyclopropylmethyl-propyl-[4-(2,4,6-trimethoxy-ph...)
Affinity DataEC50:  970nMAssay Description:Effective dose against human Corticotropin releasing factor receptor 1 stimulated ACTH release from primary rat anterior pituitary cell culturesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144193(Dicyclopropylmethyl-propyl-[4-(2,4,6-trimethoxy-ph...)
Affinity DataEC50:  990nMAssay Description:Effective dose against CRF stimulated cAMP production in CHO cells expressing human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed