BDBM50144204 CHEMBL63989::[4-(2-Chloro-4,6-dimethoxy-phenyl)-pyrimidin-2-yl]-dicyclopropylmethyl-propyl-amine

SMILES CCCN(C(C1CC1)C1CC1)c1nccc(n1)-c1c(Cl)cc(OC)cc1OC

InChI Key InChIKey=SPFHQARDCUZUIU-UHFFFAOYSA-N

Data  1 KI  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50144204   

TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144204([4-(2-Chloro-4,6-dimethoxy-phenyl)-pyrimidin-2-yl]...)
Affinity DataKi:  11nMAssay Description:Binding affinity towards human Corticotropin releasing factor receptor 1 by the displacement of [125I]CRF from CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144204([4-(2-Chloro-4,6-dimethoxy-phenyl)-pyrimidin-2-yl]...)
Affinity DataEC50:  1.10E+3nMAssay Description:Effective dose against human Corticotropin releasing factor receptor 1 stimulated ACTH release from primary rat anterior pituitary cell culturesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCorticotropin-releasing factor receptor 1(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50144204([4-(2-Chloro-4,6-dimethoxy-phenyl)-pyrimidin-2-yl]...)
Affinity DataEC50:  1.60E+3nMAssay Description:Effective dose against CRF stimulated cAMP production in CHO cells expressing human Corticotropin releasing factor receptor 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed