BDBM50145351 1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-pyridin-1-yl]-ethyl}-isochroman-6-carboxylic acid amide::CHEMBL310082

SMILES NC(=O)c1ccc2C(CCN3CCC(=CC3)c3ccc4cc(F)ccc4c3)OCCc2c1

InChI Key InChIKey=OKKGMDDMZPMRPO-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50145351   

TargetSodium-dependent serotonin transporter(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145351(1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  2.20nMAssay Description:In vitro binding affinity towards serotonin transporter using [3H]citalopram as radioligand in rat cerebral cortex membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
LigandPNGBDBM50145351(1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  36nMAssay Description:Binding affinity determined against alpha-1 adrenergic receptor in rat cortex membranes using [3H]prazosin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145351(1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  71nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1D receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Rat)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145351(1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-...)
Affinity DataKi:  491nMAssay Description:Binding affinity determined against dopamine receptor D2 in rat caudate membranes using [3H]- raclopride as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50145351(1-{2-[4-(6-Fluoro-naphthalen-2-yl)-3,6-dihydro-2H-...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity towards human 5-hydroxytryptamine 1B receptor in L-M(tk-) cells using [3H]GR-125743 as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2012
Entry Details Article
PubMed