BDBM50145572 3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-1-[4-(4-methyl-piperazin-1-yl)-cyclohexyl]-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine::CHEMBL431407

SMILES COc1cc(ccc1NCc1ccco1)-c1nn([C@H]2CC[C@@H](CC2)N2CCN(C)CC2)c2ncnc(N)c12

InChI Key InChIKey=STDSMFMGPYMGRQ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50145572   

TargetTyrosine-protein kinase Lck(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50: 64nMAssay Description:Inhibition of p56 Lck tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50: 97nMAssay Description:Inhibition of Src protein tyrosine kinase activity with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50145572(3-{4-[(Furan-2-ylmethyl)-amino]-3-methoxy-phenyl}-...)
Affinity DataIC50: 1.02E+3nMAssay Description:Inhibition of tyrosine protein kinase receptor TIE-2 with 1 mM ATP and biotinylated lck peptideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed