BDBM50148072 4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17S)-12-oxa-4-azapentacyclo[9.6.1.01,13.05,17.07,18]octadeca-7(18),8,10-trien-14-one::CHEMBL321170

SMILES O=C1CC[C@@]2(OCCCc3ccccc3)[C@H]3Cc4cccc5OC1C2(CCN3CC1CC1)c45

InChI Key InChIKey=GJFLZGCDXSDABO-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50148072   

TargetMu-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataEC50:  9.80nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataEC50:  87nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataKi:  840nMAssay Description:Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataKi:  2.28E+4nMAssay Description:Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148072(4-cyclopropylmethyl-17-(3-phenylpropoxy)-(1S,5R,17...)
Affinity DataKi:  4.62E+4nMAssay Description:Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed