BDBM50148073 17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy)-(1R,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::CHEMBL110640

SMILES COc1cccc2C[C@H]3N(CC4CC4)CCC4(CC(=O)CC[C@@]34OCCCc3ccccc3)c12

InChI Key InChIKey=UFAUQZKEVAHHCZ-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50148073   

TargetMu-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataEC50:  2nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataEC50:  21nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataKi:  340nMAssay Description:Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataKi:  7.36E+3nMAssay Description:Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataEC50: >1.00E+4nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148073(17-cyclopropylmethyl-3-methoxy-10-(3-phenylpropoxy...)
Affinity DataKi:  1.69E+4nMAssay Description:Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed